metex®

Ingrediente ativo

Methotrexat (MTX)

Modo de ação

Methotrexate is a folic acid antagonist which belongs to the class of cytotoxic agents. It acts by the competitive inhibition of the enzyme dihydrofolate reductase and thus inhibits DNA synthesis. Methotrexate is a very well-known so-called disease modifying antirheumatic drug (DMARD) meaning that it does not just relieve the pain of patients with joint inflammation and/or psoriasis, but actually helps to stop and prevent this inflammation and the resulting damage.

Indicação

• Active rheumatoid arthritis in adult patients
• Polyarthritic forms of severe, active juvenile idiopathic arthritis, when the response to nonsteroidal anti-inflammatory drugs (NSAIDs) has been inadequate
• Severe recalcitrant disabling psoriasis, which is not adequately responsive to other forms of therapy such as phototherapy, PUVA, and retinoids, and severe psoriatic arthritis in adult patients
• Mild to moderate Crohn's disease either alone or in combination with corticosteroids in adult patients refractory or intolerant to thiopurines

Dosagem

Solução injectável:

• 7.5 mg (0.15 ml)
• 10 mg (0.2 ml)
• 12.5 mg (0.25 ml)
• 15 mg (0.3 ml)
• 17.5 mg (0.35 ml)
• 20 mg (0.4 ml)
• 22.5 mg (0.45 ml)
• 25 mg (0.5 ml)
• 27.5 mg (0.55 ml)
• 30 mg (0.6 ml)